Does Insulinlike Growth Factor-I Have Anabolic Effects?
( Advanced Sports Drugs Science & Overall Wellness Studies ) ..
Insulinlike growth factor-I is considered to be the real cause of many of the beneficial effects in the body attributed to growth hormone. Girl stimulates the production of lGF-I, as it's called, in liver and other tissues. Unlike Cl-I, which is rapidly broken down in the liver,
IGF-I gradually peaks after 12 to 24 hours. Structurally IGF-I looks a lot like insulin; hence its name.
One problem with GH therapy is that it raises blood glucose levels and promotes insulin insensitivity. This is particularly true under stress conditions or when a person is taking cortisol-like drugs. IGF-I causes many of the effects of CH, such as inhibiting Fat synthesis, but
past studies showed it didn't appear to duplicate growth hormone's anabolic effects.
A new study explains this phenomenon. The researchers gave IGF-I for five days to people who were also using prednisone, a cortisone drug that promotes protein catabolism in the body. The results showed that IGF-I completely prevents cortisol's catabolic effects on muscle. In
addition, ICE-I appears to have an anabolic effect similar to insulin without causing negative effects on blood glucose.
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